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DMSO as a Dual Carbon Synthon and Water as Oxygen Donor for the Construction of 1,3,5-Oxadiazines from Amidines. | LitMetric
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DMSO as a Dual Carbon Synthon and Water as Oxygen Donor for the Construction of 1,3,5-Oxadiazines from Amidines.

Yi Zhang Jinqiang Kuang Xuqiong Xiao Lei Wang Yongmin Ma

Org Lett

Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P.R. China.

Published: May 2021

A selective and efficient synthesis of diaryl 1,3,5-oxadiazines was established for the first time from simple and readily available amidines in wet DMSO. DMSO was employed as a dual carbon synthon and water offered the oxygen atom to construct the oxadiazine ring. The reaction involved two new C-N and two new C-O bond formations.

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 Source
http://dx.doi.org/10.1021/acs.orglett.1c01116DOI Listing

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