AI Article Synopsis
- Sulfonamide compounds are essential in medicine, serving as the basis for various drugs due to their pharmacological activities like anti-carbonic anhydrase and anti-t dihydropteroate synthetase.
- Sulfamethazine (SMZ) and sulfadiazine (SDZ) are prominent sulfonamides, used respectively for treating bacterial infections in livestock and in combination with pyrimethamine for toxoplasmosis in warm-blooded animals.
- The study examines SMZ and SDZ's chemical structures, antibacterial properties, toxicity, and environmental impact, offering insights into their research findings and usage in medical and veterinary contexts.
Article Abstract
Sulfonamide (or sulphonamide) functional group chemistry (SN) forms the basis of several groups of drug. In vivo sulfonamides exhibit a range of pharmacological activities, such as anti-carbonic anhydrase and anti-t dihydropteroate synthetase allowing them to play a role in treating a diverse range of disease states such as diuresis, hypoglycemia, thyroiditis, inflammation, and glaucoma. Sulfamethazine (SMZ) is a commonly used sulphonamide drug in veterinary medicine that acts as an antibacterial compound to treat livestock diseases such as gastrointestinal and respiratory tract infections. Sulfadiazine (SDZ) is another frequently employed sulphonamide drug that is used in combination with the anti-malarial drug pyrimethamine to treat toxoplasmosis in warm-blooded animals. This study explores the research findings and the work behaviours of SN (SMZ and SDZ) drugs. The areas covered include SN drug structure, SN drug antibacterial activity, SN drug toxicity, and SN environmental toxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889 | PMC |
| http://dx.doi.org/10.1007/s12551-021-00795-9 | DOI Listing |
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