Disulfiram is one of the most common agents used for the treatment of alcoholism. A study was made of disulfiram influence on the level of testosterone and spermiogenesis in 20 alcoholic patients during course therapy. The level of testosterone was investigated before treatment and 15 and 30 days after treatment with disulfiram at a daily dose of 0.5 g. Sixteen patients of the control group received tranquilizers. Ejaculation specimens were studied before treatment and 30 days after the onset of a therapeutic course. Disulfiram therapy was shown to cause the reduction of the level of testosterone as compared to its basal level and deterioration of spermiogenesis indices as compared to the controls receiving tranquilizers. It should be borne in mind during prolonged therapeutic courses.
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