AI Article Synopsis
- A systematic review and meta-analysis were conducted to assess the effectiveness (VE) and duration of protection of both whole-cell (wP) and acellular (aP) pertussis vaccines, addressing gaps from previous studies.
- The analysis indicates that while any pertussis vaccine provides short-term protection against the disease, the protection from the acellular vaccine wanes quickly.
- Significant variability in VE estimates was observed, influenced by biases and confounding factors, highlighting the need for careful study design in future research to improve reliability of findings.
Article Abstract
A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (aP) pertussis vaccines and conducted a formal meta-analysis using random effects models. Evidence continues to suggest that receipt of any pertussis vaccine confers protection in the short-term against disease although this protection wanes rapidly for aP vaccine. We detected significant heterogeneity in pooled estimates due, in part, to factors such as bias and confounding which may be mitigated by study design. Our review of possible sources of heterogeneity may help interpretation of other VE studies and aid design decisions in future pertussis VE research.
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| http://dx.doi.org/10.1016/j.vaccine.2021.04.032 | DOI Listing |
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