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Inflammation-induced Generation of Splenic Erythroblast-like Ter- Cells Inhibits the Progression of Acute Lung Injury via Artemin.
Am J Respir Cell Mol Biol
January 2025
Second Military Medical University First Hospital, Department of Respiratory and Critical Care Medicine, Shanghai, China;
Identifying inflammation-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding the progession of ALI/ARDS. Nevertheless, how primary inflammation-induced non-leukocyte populations in distal organs contribute to ALI/ARDS remains poorly defined. Here, we report one population of erythroblast-like cells (Ter-cells) deriving from megakaryocyte- erythroid progenitor cells with a unique Ter-119+CD45-CD71+ phenotype in ALI/ARDS.
View Article and Find Full Text PDFProgressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation.
Blood
December 2024
Institut Gustave Roussy, Villejuif, France.
Pediatric acute myeloid leukemia frequently harbor fusion oncogenes associated with poor prognosis, including KMT2A, NUP98 and GLIS2 rearrangements. While murine models have demonstrated their leukemogenic activities, the steps from a normal human cell to leukemic blasts remain unclear. Here, we precisely reproduced the inversion of chromosome 16 resulting in ETO2::GLIS2 fusion in human induced pluripotent stem cells (iPSC).
View Article and Find Full Text PDFSET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia.
Genes Dis
March 2025
Pediatric Hematology-Oncology, Department of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues.
Pathol Int
December 2024
Department of Obstetrics and Gynecology, Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan.
Article Synopsis
- Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) presents similarly to acute megakaryoblastic leukemia but usually resolves on its own within months postpartum.
- Some cases of TAM can lead to severe health issues, impacting the patient's prognosis negatively.
- An autopsy of a stillborn female with TAM and DS revealed GATA1s protein expression in unusual immature megakaryocytes, indicating that placental tissue can be useful for diagnosing TAM histologically.
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