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[Progress of researches on antiparasitic activities of scorpion venoms and their antimicrobial peptides].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2024
Mongolian Medical College, Inner Mongolia Minzu University; National Medical Products Administration Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), Tongliao, Inner Mongolia 028043, China.
Scorpion venom is a highly complicated cocktail of bioactive components including mucoproteins, enzymes, lipids, bioactive peptides, and other organic or inorganic molecules. Scorpion venom antimicrobial peptides are a class of small-molecule bioactive peptides extracted from scorpion venoms, which have shown a variety of biological activities, including antiviral, antibacterial, antifungal and antitumor actions. This review describes the progress of researches on the antiparasitic activities of scorpion venoms and their antimicrobial peptides, so as to provide insights into the research and development of novel antiparasitic agents.
View Article and Find Full Text PDFAn unveiling case of Nocardia pansinusitis in a patient with chronic lymphocytic leukemia: a case report.
J Med Case Rep
January 2025
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
Background: Nocardia infections are rare infections in immunocompetent patients and occur mostly in immunocompromised individuals. Usually, nocardia affects skin, brain, and lungs, but in disseminated forms, which occurred mostly in immunocompromised patients, it can involve every organ. Nocardia sinusitis is extremely rare as our searches returned only a very few related studies.
View Article and Find Full Text PDFStructural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents.
Malar J
January 2025
Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Background: The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages.
Methods: In this investigation, a comparative analysis was conducted on the structural features of the β5 subunit in the 20S proteasomes of both Plasmodium and humans.
Results: The findings underscore the structural diversity inherent in both proteasomes.
transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance.
Front Cell Infect Microbiol
January 2025
National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Introduction: A continuing challenge for malaria control is the ability of to develop resistance to antimalarial drugs. Members within the transcription factor family AP2 regulate the growth and development of the parasite, and are also thought to be involved in unclear aspects of drug resistance. Here we screened for single nucleotide polymorphisms (SNPs) within the AP2 family and identified 6 non-synonymous mutations within AP2-06B (PF3D7_0613800), with allele frequencies greater than 0.
View Article and Find Full Text PDFBeyond destruction: emerging roles of the E3 ubiquitin ligase Hakai.
Cell Mol Biol Lett
January 2025
Epithelial Plasticity and Metastasis Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), Xubias de Arriba 84, 15006, A Coruña, Spain.
Hakai protein (CBLL1 gene) was identified as an E3 ubiquitin ligase of E-cadherin complex, inducing its ubiquitination and degradation, thus inducing epithelial-to-mesenchymal transition. Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of its E3 ubiquitin ligase activity, underscoring its involvement in the N-methyladenosine (mA) writer complex and its impact on the methylation of RNA.
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