Background: Step length asymmetry is common after stroke. Unilateral step training (UST) can improve step length asymmetry for patients who take a longer step with their paretic leg (P-long). UST has not been tested with patients who take a shorter step with their paretic leg (P-short).
Research Question: Does training patients according to the direction of their asymmetry improve step length asymmetry?
Methods: Adults 18 years and older with asymmetrical gait at least 6 months post-stroke completed three 20 min treadmill training sessions at least 48 h apart: Conventional treadmill; UST with the non-paretic leg stationary on the side of the treadmill and the paretic leg stepping on the moving treadmill belt (P-stepping); and UST with the paretic leg stationary on the side of the treadmill and the non-paretic leg stepping on the moving belt (NP-stepping). Spatiotemporal gait parameters before, immediately, 10 min and 30 min after training were recorded at self-selected and fastest walking pace. Asymmetry values for each parameter were calculated. RmANOVAs were used to investigate the effects of training type on spatiotemporal parameters and paired-samples t-tests used to investigate potential contributors to training effects on asymmetry.
Results: Twenty participants (16 male, median age 65 (43-80) years; 11 P-long, 9 P-short) were included. Improvements in step length asymmetry were observed immediately after both Conventional (9.1 %; 95 % CI 2.7-15.4%) and P-stepping (11.6 %; 95 % CI 5.3-17.8 %) treadmill training in participants who take a shorter step with their paretic leg, however effects were only sustained after Conventional training. Step length asymmetry did not improve for P-long participants with any training type.
Significance: The effectiveness of unilateral step training may be related to the direction of step length asymmetry. Further investigation is required before considering using unilateral step training as a rehabilitation tool for gait asymmetry after stroke.
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http://dx.doi.org/10.1016/j.gaitpost.2021.04.035 | DOI Listing |
Brief Bioinform
November 2024
Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceutical Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
Antibody generation requires the use of one or more time-consuming methods, namely animal immunization, and in vitro display technologies. However, the recent availability of large amounts of antibody sequence and structural data in the public domain along with the advent of generative deep learning algorithms raises the possibility of computationally generating novel antibody sequences with desirable developability attributes. Here, we describe a deep learning model for computationally generating libraries of highly human antibody variable regions whose intrinsic physicochemical properties resemble those of the variable regions of the marketed antibody-based biotherapeutics (medicine-likeness).
View Article and Find Full Text PDFAoB Plants
January 2025
Department of Biology, Loyola University Chicago 1032 W. Sheridan Rd. Chicago, IL 60660, United States.
The shift from outcrossing to predominantly selfing is one of the most common transitions in plant evolution. This evolutionary shift has received considerable attention from biologists; however, this work has almost exclusively been focused on animal-pollinated systems. Despite the seminal ecological and economic importance of wind-pollinated species, the mechanisms controlling the degree of outcrossing in wind-pollinated taxa remain poorly understood.
View Article and Find Full Text PDFChild Youth Serv Rev
July 2024
Department of Psychology, Arizona State University, Tempe, AZ, USA.
Introduction: Parenting programs are widely used to prevent and ameliorate children's emotional and behavioral problems but low levels of engagement undermine intervention effectiveness and reach within and beyond research settings. Technology can provide flexible and cost-effective alternate service-delivery formats for parenting programs, and studies are needed to assess the extent to which parents are willing to engage with digitally assisted formats.
Methods: After Deployment, Adaptive Parenting Tools (ADAPT) is an evidence-based parenting program for military families.
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Methods: Forty-eight patients with unstable distal radius fractures between January 2022 and February 2023 were retrospectively analyzed and divided into the CO external fixation group and internal fixation group. CO external fixation group consisted of 25 patients, including 7 males and 18 females, aged from 37 to 56 years old with an average of ( 52.
Small
January 2025
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Omniphobic surfaces, which repel virtually any liquid regardless of its wettability, have been developed using doubly re-entrant microstructures. Although various microfabrication techniques have been explored, these often require multiple complex steps. In this study, reaction-diffusion photolithography (RDP) is used to fabricate micropost arrays with doubly re-entrant geometries through a single-step ultraviolet (UV) exposure process.
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