Immune response to SARS-CoV-2 infection and vaccination in patients receiving kidney replacement therapy.

Kidney Int

Unité Mixte de Recherche S 1155, Sorbonne Université, Université Pierre et Marie Curie Paris 06 and Institut National de la Santé et de la Recherche Médicale, Paris, France; Division of Nephrology, Centre Hospitalier du Mans, Le Mans, France.

Published: June 2021

AI Article Synopsis

  • The issue discusses the immunogenicity of COVID-19 in patients on maintenance dialysis and kidney transplant recipients, highlighting their initial experiences with both prior infections and vaccination responses.
  • Preliminary findings indicate that patients maintain a durable immune response after recovering from COVID-19.
  • While dialysis patients develop strong antibody responses after the second vaccine dose, kidney transplant recipients exhibit a weaker immune response compared to both healthy individuals and dialysis patients.

Article Abstract

In this issue of Kidney International, the initial experience regarding the immunogenicity of prior coronavirus disease 2019 (COVID-19) infection and the response to the COVID-19 vaccines among patients on maintenance dialysis and kidney transplant recipients is summarized. Preliminary data suggest that there is durability of immune response after COVID-19 infection. Although immune response to the first dose of vaccine is less in infection-naïve patients than healthy individuals in both groups, after the second vaccine dose a significant portion of patients receiving maintenance dialysis develop robust antibody titers, whereas kidney transplant recipients show a less-strong immune response.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055920PMC
http://dx.doi.org/10.1016/j.kint.2021.04.007DOI Listing

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