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Tumor Microenvironment-Driven Structural Transformation of Vanadium-Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy.
Adv Sci (Weinh)
January 2025
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal catalytic efficiency and kinetics in the tumor microenvironment (TME). Herein, this study draws inspiration from the electronic structure of transition metal vanadium, proposing the leverage of TME specific-features to induce structural transformations in sheet-like vanadium carbide MXenzymes (TVMz). These transformations trigger cascading catalytic reactions that amplify oxidative stress, thereby significantly enhancing multimodal tumor therapy.
View Article and Find Full Text PDFApplication of modified solidified soil in in-situ backfilling of coal gangue: evaluation of arsenic stabilization effect and mechanism study.
Environ Geochem Health
January 2025
School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, Beijing, 100083, China.
As a typical ecologically fragile area, the Wudong Coal Mine region in Xinjiang generates large accumulations of coal gangue each year, which, in the alkaline soil environment, can easily lead to significant leaching and accumulation of As. This study developed a stabilizer (CFD) using cement, fly ash, and desulfurized gypsum to modify in-situ soil in the Xinjiang mining area, resulting in a modified solidified soil with excellent geotechnical performance and As stabilization capability. The study results showed that when CFD content exceeded 14.
View Article and Find Full Text PDFFoamy Melamine Resin-Silica Aerogel Composite-Derived Thermal Insulation Coating.
Nanomaterials (Basel)
January 2025
State Key Laboratory of High-Performance Civil Engineering Materials, Jiangsu Sobute New Materials Co., Ltd., Nanjing 210008, China.
A novel class of SiO aerogel-based resin composite with a self-formed foamy structure and an extremely low thermal conductivity, as well as excellent fire resistance, was fabricated via a room temperature and atmospheric pressure route. The self-formed foamy structure was achieved by utilizing SiO aerogel particles not only as a thermal insulative functional additive filler but also as nano-sized solid particles in a Picking emulsion system, adjusting the surface tension as a stabilizer at the interface between the two immiscible phases (liquid and air in this case). The results of foamy structure analyses via scanning electron microscopy, micro-CT, and N adsorption-desorption isotherms validate the successful generation of a micro-scale porous structure with the enhancement of the aerogel nano-scale solid particles at the wall as a stabilizer.
View Article and Find Full Text PDFStructure Diversity and Properties of Some Bola-like Natural Products.
Mar Drugs
December 2024
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
In their shapes, molecules of some bipolar metabolites resemble the so-called bola, a hunting weapon of the South American inhabitants, consisting of two heavy balls connected to each other by a long flexible cord. Herein, we discuss the structures and properties of these natural products (bola-like compounds or bolaamphiphiles), containing two polar terminal fragments and a non-polar chain (or chains) between them, from archaea, bacteria, and marine invertebrates. Additional modifications of core compounds of this class, for example, interchain and intrachain cyclization, hydroxylation, methylation, etc.
View Article and Find Full Text PDFMetaboLabPy-An Open-Source Software Package for Metabolomics NMR Data Processing and Metabolic Tracer Data Analysis.
Metabolites
January 2025
Department of Metabolism and Systems Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK.
NMR spectroscopy is a powerful technique for studying metabolism, either in metabolomics settings or through tracing with stable isotope-enriched metabolic precursors. MetaboLabPy (version 0.9.
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