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A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide. | LitMetric
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A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide.

Ruben L H Andringa Niels A W de Kok Arnold J M Driessen Adriaan J Minnaard

Angew Chem Int Ed Engl

Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.

Published: August 2021

Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362178PMC
http://dx.doi.org/10.1002/anie.202104759DOI Listing

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