Agriculture Exposure and Time to Pregnancy Among Women Enrolled in the French Prospective Cohort AGRICAN.

J Occup Environ Med

Université de Caen Normandie (Dr Pons, Dr Boulanger, Ms Busson, Ms Renier, Dr Lebailly), France; French National Institute of Health and Medical Research (Inserm); Unité Mixte de Recherche (UMR) 1086 ANTICIPE (Dr Pons, Dr Boulanger, Dr Tual, Ms Busson, Ms Renier, Ms Perrier, Ms Levêque-Morlais, Dr Lebailly), Caen, France; Comprehensive Cancer Centrer François Baclesse (Dr Boulanger, Dr Tual, Ms Perrier, Ms Levêque-Morlais, Dr Lebailly) Caen, France; Central Agricultural Social Insurance (CCMSA), Echelon National Santé Sécurité au Travail, Bobigny (Dr Marcotullio), France; French National Institute of Health and Medical Research (Inserm), Population Health Research Center, Team EPICENE Unité Mixte de Recherche (UMR) 1219, Université de Bordeaux (Dr Baldi), France; CHU de Bordeaux, Pôle de Santé Publique, Service Santé Travail Environnement (Dr Baldi), Bordeaux, France.

Published: May 2021

AI Article Synopsis

  • The study aimed to explore the relationship between time-to-pregnancy (TTP) and exposure to agricultural work and pesticides among women in the AGRICAN cohort.
  • Data was collected from 616 women who reported pregnancies between 2005 and 2017, analyzing their farming activities and conditions prior to conception.
  • Results indicated a non-significant decrease in fecundability linked to farm work, night shifts, and exposure to vibrations, suggesting that these factors may contribute to a longer time-to-pregnancy.

Article Abstract

Objectives: In few retrospective studies, prolonged time-to-pregnancy (TTP) was observed for women exposed to pesticides especially in flower production. The present study investigated time-to-pregnancy in the AGRICAN cohort.

Methods: Analyses were performed on 616 women reporting a pregnancy (2005 to 2017), and data on agricultural activities performed before the last pregnancy was retrospectively collected. Fecundability odds ratios (fOR) were estimated using a discrete time analogue of Cox proportional hazard model adjusted on maternal and paternal age, body mass index (BMI), and alcohol consumption.

Results: A decrease in fecundability was non-significantly associated with farm work (adjusted fOR = 0.86; 95% confidence interval [CI]: 0.71 to 1.05). Decreases were also observed for nightwork (afOR = 0.75; 95% CI: 0.49 to 1.15) and exposure to vibrations (afOR = 0.68; 95% CI: 0.43 to 1.09).

Conclusion: Women working on a farm before conception appeared to experience a longer TTP. Negative associations were suggested for some agricultural activities and working conditions.

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Source
http://dx.doi.org/10.1097/JOM.0000000000002163DOI Listing

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