AI Article Synopsis
- CSNK2B is highly expressed in colorectal cancer (CRC) tissues compared to normal tissues, indicating its potential role in cancer development.
- Experiments showed that increased CSNK2B levels enhance CRC cell survival and tumor growth, suggesting it promotes cancer progression.
- The study reveals that CSNK2B acts as an oncogene primarily by activating the mTOR signaling pathway, contributing to CRC proliferation.
Article Abstract
The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222461 | PMC |
| http://dx.doi.org/10.1007/s12079-021-00619-1 | DOI Listing |
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