Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370576 | PMC |
| http://dx.doi.org/10.1038/s41594-021-00585-7 | DOI Listing |
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