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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies.
PLoS Pathog
January 2025
Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy of novel pan-orthohantavirus countermeasures. Here, we describe the use of a human lung xenograft mouse model to study the permissiveness for different orthohantavirus species and to assess its utility for preclinical testing of therapeutics.
View Article and Find Full Text PDF[Analysis of the surveillance system for adverse events following Immunization (AEFI) related to COVID-19 vaccines in Colombia, 2021-2023Análise do sistema de vigilância de ESAVI por vacinas contra a COVID-19 na Colômbia, 2021-2023].
Rev Panam Salud Publica
January 2025
Organización Panamericana de la Salud Washington D. C. Estados Unidos Organización Panamericana de la Salud, Washington D. C., Estados Unidos.
Objective: To describe the functioning of the surveillance system for adverse events following immunization (AEFI) in Colombia using the evaluation tools proposed by the World Health Organization (WHO).
Method: Descriptive study of the performance of the AEFI surveillance system for COVID-19 vaccines between 17 February 2021 and 30 September 2023. WHO indicators for structure, process, and results were adapted.
Communicating the interdependence of human, animal, and environmental health on X (formerly Twitter): Insights from the one health approach.
iScience
January 2025
Department of Biology and Geology, Universidad de Almería, La Cañada de San Urbano, 04120 Almería, Spain.
The COVID-19 pandemic has underscored societies' need for education and preparedness in addressing global environmental and health crises. Raising public awareness of the interdependence of human, animal, and environmental health is essential to engaging the public in environmental conservation and disease prevention. The One Health approach offers a holistic and multidisciplinary view for tackling challenges related to environmental and health issues by emphasizing the interplay of these three interconnected health dimensions.
View Article and Find Full Text PDFAdaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial.
BMJ Open
January 2025
Department of Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Introduction: Despite repeated vaccinations against SARS-CoV-2 virus, patients who are immunocompromised remain at very high risk of catching SARS-CoV-2 virus and becoming unwell. AZD7442 (Evusheld) is a long-acting monoclonal antibody treatment that has been shown in clinical trials to prevent SARS-CoV-2 infection for up to a year after a single dose. Vaccines require a healthy immune system to generate protective immunity.
View Article and Find Full Text PDFDigital Health Intervention (SANGYAN Podcast) to Enhance Knowledge Related to COVID-19 and Other Health Conditions: Protocol for an Implementation and Evaluation Study.
JMIR Res Protoc
January 2025
Foundation of Healthcare Technologies Society, New Delhi, India.
Background: Podcasts are an unconventional method of disseminating information through audio to the masses. They are an emerging portable technology and a valuable resource that provides unlimited access for promoting health among participants. Podcasts related to health care have been used as a source of medical education, but there is a dearth of studies on the use of podcasts as a source of health information.
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