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Clinical, Pathological and Prognostic Features of Rare BRAF Mutations in Metastatic Colorectal Cancer (mCRC): A Bi-Institutional Retrospective Analysis (REBUS Study). | LitMetric
Recently, retrospective analysis began to shed light on metastatic colorectal cancers (mCRCs) harboring rare non-V600 mutations, documenting a distinct phenotype and a favorable prognosis. This study aimed to confirm features and prognosis of rare non-V600 mCRCs compared to V600E and wild-type mCRCs treated at two Italian Institutions. Overall, 537 cases were retrospectively evaluated: 221 wild-type, 261 mutated, 46 V600E and 9 non-V600. Compared to V600E mCRC, non-V600 mCRC were more frequently left-sided, had a lower tumor burden and displayed a lower grade and an MMR proficient/MSS status. In addition, non-V600 mCRC patients underwent more frequently to resection of metastases with radical intent. Median overall survival (mOS) was significantly longer in the non-V600 compared to the V600E group. At multivariate analysis, only age < 65 years and ECOG PS 0 were identified as independent predictors of better OS. V600E mCRCs showed a statistically significant worse mOS when compared to wild-type mCRCs, whereas no significant difference was observed between non-V600 and wild-type mCRCs. Our study corroborates available evidence concerning incidence, clinicopathologic characteristics and prognosis of -mutated mCRCs.
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