Antimalarial Effect of the Total Glycosides of the Medicinal Plant, .

In traditional Chinese medicine, has been used to treat various diseases, including malaria, and the young stem of is consumed as a food in the Republic of Korea. However, experimental evidence of the antimalarial effect of has not been evaluated. Therefore, the antimalarial activity of the extract of the young stem of was evaluated in vitro using both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains; in vivo activity was evaluated in -infected mice via oral administration followed by a four-day suppressive test focused on biochemical and hematological parameters. Exposure to extracts of resulted in significant inhibition of both chloroquine-sensitive (3D7) and resistant (Dd2) strains of with IC values of 6.29 ± 2.78 and 5.36 ± 4.93 μg/mL, respectively. Administration of also resulted in potent antimalarial activity against in infected mice with no associated toxicity; treatment also resulted in improved hepatic, renal, and hematologic parameters. These results demonstrate the antimalarial effects of both in vitro and in vivo with no apparent toxicity.