Neuroprotective and Antioxidant Enhancing Properties of Selective Extracts.

The sterile stems belonging to the species are often used in traditional medicine of various nations, including Romanians. They are highly efficient in treating urinary tract infections, cardiovascular diseases, respiratory tract infections, and medical skin conditions due to their content of polyphenolic derivatives that have been isolated. In this regard, this study aimed to provide the chemical composition of the extracts obtained from the species (, , ) and to investigate the biological action in vitro and in vivo. For the chemical characterization of the analyzed species extracts, studies were performed by using ultra-high-performance liquid chromatography (UHPLC-DAD). In vitro evaluation of the antioxidant activity of the plant extracts obtained from these species of genus was determined. The neuroprotective activity of these three ethanolic extracts from the species using zebrafish tests was determined in vivo. All obtained results were statistically significant. The results indicate that extract has a significant antioxidant activity; whereas, extract had anxiolytic and antidepressant effects significantly higher than the other two extracts used. All these determinations indicate promising results for the antioxidant in vitro tests and neuroprotective activity of in vivo tests, particularly mediated by their active principles.