Currently used elaborate technologies for the detection of bacteria can be improved in regard to their time consumption, labor intensity, accuracy and reproducibility. Well-known electrical measurement methods might connect highly sensitive sensing systems with biological requirements. The development of modified sensor surfaces with self-assembled monolayers (SAMs) from functionalized porphyrin for bacteria trapping can lead to a highly sensitive sensor for bacteria detection. Different ABC-type porphyrin structures were synthesized and examined regarding their optical behavior. We achieved the synthesis of a porphyrin for SAM formation on a gold surface as electrode material. Two possible bio linkers were attached on the opposite -position of the porphyrin, which allows the porphyrin to react as a linker on the surface for bacteria trapping. Different porphyrin structures were attached to a gold surface, the SAM formation and the respective coverage was investigated.
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http://dx.doi.org/10.3390/ma14081934 | DOI Listing |
Int J Biol Macromol
January 2025
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China. Electronic address:
Functional coating materials have found extensive applications across various technological fields. However, the effectiveness of these coating depends critically on the choice of an appropriate medium. In this study, we developed an advanced "molecular glue", a CsgA variant known as CsgA-pro, which can serve as a versatile medium for biotherapy.
View Article and Find Full Text PDFTalanta
January 2025
State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania; Pharmacy and Pharmacology Center, Faculty of Medicine, Vilnius University, Ciurlionio str. 21, Vilnius, Lithuania. Electronic address:
Many vaccines have been produced during the COVID-19 pandemic. Currently, an increasing number of vaccines have reached an expiration date without being used. Therefore, expired vaccines (EXVAX) based on virus-like particles (VLP) recombinant SARS-CoV2-S protein can be repurposed for biosensing application and provide a use, even though they are past their expiration date for vaccination.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Graduate School of Science and Engineering, Kindai University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Selective modification of chemically active sites on supports, such as steps, edges, and corners, with metal nanoparticles (NPs) is a challenging topic in the fields of catalysis and photocatalysis. However, the formation of site-selective, high-density metal NPs on a support has not yet been achieved. Radial ZnO mesocrystals composed of hexagonal nanowires (NWs) with {101̅0} sidewalls were synthesized by a simple solution-phase method.
View Article and Find Full Text PDFBioanalysis
January 2025
College of Chemistry, Beijing University of Chemical Technology, Beijing, China.
Ultrasmall and highly fluorescent gold nanoclusters (Au NCs) have been widely used for the construction of sensing and imaging platforms. Specifically, through a combination of surface functionalization and spectral analysis and/or imaging techniques, effective intracellular detection and imaging are realized. In this review, we summarize the recently adopted intracellular analysis and imaging events with Au NCs-based probes.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
EaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, U.K.
Nanoparticles of highly porous metal-organic frameworks (MOFs) are some of the most exciting nanomaterials under development, with potential applications that range from biomedicine and catalysis to adsorption technologies. However, our synthetic methodologies to functionalize and manipulate MOF nanoparticles (NPs) are less well developed than they might be. Here we create MOF NPs derivatized with hydrazone units on their exterior, enabling chemospecific reversible dynamic covalent modification of structures on the external surface.
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