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Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses. | LitMetric

AI Article Synopsis

  • Stress is a common negative feeling, and while traditional strategies to combat it include relaxation techniques and medications, recent research shows that non-deceptive placebos can also help reduce stress levels.
  • A study involving 53 healthy participants tested the effects of these placebos during a stress test, measuring both self-reported stress and cortisol levels.
  • Results indicated that people with a strong belief in the effectiveness of placebos experienced significantly lower anxiety and cortisol responses, suggesting that open-label placebos could be a beneficial treatment option for stress in certain individuals.

Article Abstract

Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative emotional stress. While it is widely held that placebos require deception to provoke a response, recent studies demonstrate intriguing evidence that placebos may work even without concealment (e.g., against anxiety or pain). Most of these studies are based on self-report questionnaires and do not include physiological measures. Here we report results of a study examining whether placebos without deception reduce acute stress. A total of 53 healthy individuals received either placebos without deception or no pills before participating in a laboratory stress test (Maastricht Acute Stress Test, MAST). We recorded self-report stress measures and cortisol responses before and after the MAST. Results showed no significant differences between the placebo and the control group, but when comparing participants with high relative to low beliefs in the power of placebos we found significant lower anxiety and cortisol responses for the placebo believers. These results show that non-deceptive placebos may successfully reduce acute anxiety and stress, but only in participants who had a strong belief in placebos. We discuss the results by suggesting that open-label placebos might be a possible treatment to reduce stress at least for some individuals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072693PMC
http://dx.doi.org/10.3390/brainsci11040508DOI Listing

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