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Protein-Based 3D Biofabrication of Biomaterials. | LitMetric

Protein-Based 3D Biofabrication of Biomaterials.

Bioengineering (Basel)

BioMatter Unit, École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.

Published: April 2021

AI Article Synopsis

Article Abstract

Protein/peptide-based hydrogel biomaterial inks with the ability to incorporate various cells and mimic the extracellular matrix's function are promising candidates for 3D printing and biomaterials engineering. This is because proteins contain multiple functional groups as reactive sites for enzymatic, chemical modification or physical gelation or cross-linking, which is essential for the filament formation and printing processes in general. The primary mechanism in the protein gelation process is the unfolding of its native structure and its aggregation into a gel network. This network is then stabilized through both noncovalent and covalent cross-link. Diverse proteins and polypeptides can be obtained from humans, animals, or plants or can be synthetically engineered. In this review, we describe the major proteins that have been used for 3D printing, highlight their physicochemical properties in relation to 3D printing and their various tissue engineering application are discussed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073780PMC
http://dx.doi.org/10.3390/bioengineering8040048DOI Listing

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