AI Article Synopsis
- This study explored a new 3D-printed scaffold design with a dual-pore kagome structure, focusing on its effects on cell response and mechanical strength.
- The kagome scaffold showed similar compressive modulus to conventional patterns but performed better overall due to its unique structure and higher porosity.
- Results indicated that the proposed scaffold enhanced cell adhesion, growth, and alkaline phosphatase (ALP) levels over 14 days, proving its effectiveness in promoting better in vitro cell response compared to traditional scaffolding designs.
Article Abstract
In this study, we investigated the dual-pore kagome-structure design of a 3D-printed scaffold with enhanced in vitro cell response and compared the mechanical properties with 3D-printed scaffolds with conventional or offset patterns. The compressive modulus of the 3D-printed scaffold with the proposed design was found to resemble that of the 3D-printed scaffold with a conventional pattern at similar pore sizes despite higher porosity. Furthermore, the compressive modulus of the proposed scaffold surpassed that of the 3D-printed scaffold with conventional and offset patterns at similar porosities owing to the structural characteristics of the kagome structure. Regarding the in vitro cell response, cell adhesion, cell growth, and ALP concentration of the proposed scaffold for 14 days was superior to those of the control group scaffolds. Consequently, we found that the mechanical properties and in vitro cell response of the 3D-printed scaffold could be improved by kagome and dual-pore structures through DfAM. Moreover, we revealed that the dual-pore structure is effective for the in vitro cell response compared to the structures possessing conventional and offset patterns.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123325 | PMC |
| http://dx.doi.org/10.3390/polym13091394 | DOI Listing |
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