Drivers' road rage is among the main causes of road accidents. Each year, it contributes to more deaths and injuries globally. In this context, it is important to implement systems that can supervise drivers by monitoring their level of concentration during the entire driving process. In this paper, a module for Advanced Driver Assistance System is used to minimise the accidents caused by road rage, alerting the driver when a predetermined level of rage is reached, thus increasing the transportation safety. To create a system that is independent of both the orientation of the driver's face and the lighting conditions of the cabin, the proposed algorithmic pipeline integrates face detection and facial expression classification algorithms capable of handling such non-ideal situations. Moreover, road rage of the driver is estimated through a decision-making strategy based on the temporal consistency of facial expressions classified as "anger" and "disgust". Several experiments were executed to assess the performance on both a real context and three standard benchmark datasets, two of which containing non-frontal-view facial expression and one which includes facial expression recorded from participants during driving. Results obtained show that the proposed module is competent for road rage estimation through facial expression recognition on the condition of multi-pose and changing in lighting conditions, with the recognition rates that achieve state-of-art results on the selected datasets.
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http://dx.doi.org/10.3390/s21092942 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS Deemed-to-be-University, V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, India.
The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor with several structural types, performing a myriad of molecular mechanisms. The RAGE-ligand interactions play important roles in maintaining latent chronic inflammation, and oxidative damage underlying various pathological conditions like metabolic syndrome (MetS), neurodegenerative diseases, stroke, cardiovascular disorders, pulmonary disorders, cancer and infections. RAGE is thoroughly explored in knockout animals and human trials, targeted by small molecule inhibitors, peptides, diet, and natural compounds.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Department of Clinical Pharmacology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, China. Electronic address:
Qikui granule (QKG), a hospital preparation of traditional Chinese medicine, has been widely used for diabetic kidney disease (DKD) in clinical practice. However, its holistic therapeutic effects and the underlying therapeutic mechanisms remain unclear. In the present study, the integrated analysis of network pharmacology, 16S rRNA sequencing, and non-targeted lipidomics was performed to explore the anti-DKD effects of QKG and the underlying mechanisms in db/db mouse DKD model.
View Article and Find Full Text PDFHereditas
November 2024
The First Hospital of Lanzhou University, Chengguan District, No. 1 Dong Gang Xi Road, Lanzhou, Gansu, 730000, People's Republic of China.
Stem Cell Res Ther
November 2024
Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Shandong University, No.44-1 Wenhua Road West, Jinan, Shandong, 250012, China.
Background: Diabetes, occasionally diagnosed in orthodontic patients, can impede orthodontic tooth movement (OTM) by accumulating advanced glycation end products (AGEs) in the periodontium. This accumulation impairs the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) due to alterations in the force-loaded microenvironment, yet the underlying mechanisms remain elusive.
Methods: Bioinformatics analysis of GSE112122 identified alterations in the mechanical regulation of histone methylation enzyme Lysine Demethylase 6B (KDM6B).
Open Life Sci
November 2024
Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China.
Fibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by transforming growth factor (TGF)-β2. The proliferation, migration, and apoptosis of ARPE-19 cells were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, wound healing, and flow cytometry assays, and levels of fibrosis-associated and pathway-related proteins were determined by performing western blotting.
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