Keratin-associated proteins (KAPs) and keratins determine the physical and chemical properties of cashmere fibers as they are the main components of the fibers. It has been reported that ovine affects clean fleece weight, greasy fleece weight and yield in sheep, but the gene has not been described in goats and its effects on fiber traits are unknown. In this study, we identify the keratin-associated protein 1-2 gene () in the goat genome and describe its effect on cashmere fiber traits in 359 Longdong cashmere goats. Six sequence variants (named CAPHI- to CAPHI-) were revealed using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. These sequences have the highest homology with ovine sequences. There were a 60-bp deletion, a 15-bp insertion and five single nucleotide polymorphisms (SNPs) including two non-synonymous SNPs in the coding sequence. The caprine gene was expressed in the skin tissue, but a signal was not observed for the kidneys, liver, lungs, spleen, heart and muscle. Variation in caprine was found to be associated with raw cashmere fiber weight, but not with fiber diameter and length.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143586 | PMC |
| http://dx.doi.org/10.3390/genes12050625 | DOI Listing |
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