Background: Hederacoside C from ivy leaf dry extracts (HH) and berberine from dry extracts (CR) can be combined (HHCR) as a herbal product. Previous studies have demonstrated that HHCR has antitussive and expectorant effects in animal models of respiratory disease. However, the therapeutic effects of HHCR on respiratory diseases in humans have not been well-studied. Therefore, we aimed to clarify the effectiveness of HHCR in patients with chronic bronchitis and bronchiectasis.
Methods: This was a multicenter (10 university teaching hospitals), open-label, prospective, single-arm, observational study. Consecutive patients with chronic bronchitis and bronchiectasis were included. Patients were orally treated with HHCR daily for 12 weeks. St. George's Respiratory Questionnaire (SGRQ) scores and bronchitis severity scores (BSS) were measured at baseline and at the end of the 12-week study.
Results: In total, 376 patients were enrolled, of which 304 were finally included in the study, including 236 males and 68 females with a median age of 69 years (range: 37-88 years). After 12 weeks of HHCR treatment, there was a significant improvement in SGRQ score (baseline, 32.52 ± 16.93 vs. end of study, 29.08 ± 15.16; < 0.0001) and a significant reduction in BSS (baseline, 7.16 ± 2.63 vs. end of study, 4.72 ± 2.45; < 0.0001). During the study, 14 patients concomitantly used an inhaled corticosteroid and 83 patients used an inhaled bronchodilator. HHCR also had significant positive effects on these patients in terms of SGRQ score and BSS. No serious adverse drug reactions occurred during HHCR treatment.
Conclusions: treatment with HHCR improved the SGRQ score and BSS in patients with chronic bronchitis and bronchiectasis. HHCR may be a new therapeutic option for chronic bronchitis and bronchiectasis. Large-scale, randomized, double-blind, placebo-controlled clinical trials are warranted.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069972 | PMC |
| http://dx.doi.org/10.3390/ijerph18084024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Curative Treatment for COPD Based on Differentiation Induction by Synthetic Retinoid Am80 and Development of Inhalation Powder].
Yakugaku Zasshi
January 2025
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis and emphysema, and current drug treatments is limited to symptomatic therapy. Thus, there is an urgent need for development of new treatments to repair alveolar destruction. To regenerate the destroyed alveoli, we focused on the differentiation of alveolar epithelial progenitor cells into type I or type II alveolar epithelial cells that constitute the alveoli.
View Article and Find Full Text PDFAssociations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study.
Prev Med
December 2024
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
Objective: This study aimed to explore the associations between short-term air pollution exposure and acute exacerbation of chronic bronchitis (AECB).
Methods: AECB data were collected from hospital surveillance systems in Shanghai, China, during 2018-2022. Exposure pollution data were obtained from China high resolution high quality near-surface air pollution datasets and assigned to individuals based on their residential addresses.
Chronic Obstructive Pulmonary Disease: Lifestyle Impact.
Int J Prev Med
November 2024
Department of Nutrition and Dietetics, School of Allied Health Sciences, Faridabad, Haryana, India.
Article Synopsis
- Respiratory infections are a major global health issue, responsible for 7.5 million deaths annually, highlighting their impact on both health and economics.
- Chronic obstructive pulmonary disease (COPD) arises from lifestyle choices and environmental factors, necessitating interventions like smoking cessation, healthy diets, and physical activity to improve lung health.
- European health initiatives focus on early detection and prevention through awareness campaigns, vaccination programs, and nutritional support to reduce the incidence and severity of respiratory diseases.
Long-term multi-systemic complications following SARS-CoV-2 Omicron and Delta infection in children: a retrospective cohort study.
Clin Microbiol Infect
December 2024
National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Ministry of Health, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Objectives: Most studies on long-term sequelae of SARS-CoV-2-infection in children were conducted pre-Omicron and pre-dated vaccination rollout. We examined long-term risk of new-incident multi-systemic sequelae after SARS-CoV-2 Delta/Omicron infection in a multi-ethnic Asian pediatric population.
Methods: Retrospective cohort study of Singaporean children aged 1- 17 years infected during Delta/Omicron BA.
Therapeutic and Mechanistic Advances in Chronic Cough.
Ann Allergy Asthma Immunol
December 2024
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine.
Cough is one of the most common reasons patients seek medical care in the outpatient setting. Chronic cough (CC) in adults is defined as a cough lasting more than 8 weeks, with a global prevalence of approximately 10%. CC significantly impairs quality of life, affecting physical, social, and psychological well-being.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!