The marine sponge of the genus , , , and are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H () and rhabdastin I (). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds and showed activities against K562 (IC 11.7 and 9.8 μM) and Molt4 (IC 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.
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