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Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein. | LitMetric

Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein.

Viruses

CNRS, Architecture et Réactivité de l'ARN, UPR 9002, IBMC-2 Allée Konrad Roentgen, Université de Strasbourg, F-67000 Strasbourg, France.

Published: April 2021

AI Article Synopsis

Article Abstract

The ubiquitin-proteasome system plays an important role in the cell under normal physiological conditions but also during viral infections. Indeed, many auxiliary proteins from the (HIV-1) divert this system to its own advantage, notably to induce the degradation of cellular restriction factors. For instance, the HIV-1 viral infectivity factor (Vif) has been shown to specifically counteract several cellular deaminases belonging to the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 or A3) family (A3A to A3H) by recruiting an E3-ubiquitin ligase complex and inducing their polyubiquitination and degradation through the proteasome. Although this pathway has been extensively characterized so far, Vif has also been shown to impede A3s through degradation-independent processes, but research on this matter remains limited. In this review, we describe our current knowledge regarding the degradation-independent inhibition of A3s, and A3G in particular, by the HIV-1 Vif protein, the molecular mechanisms involved, and highlight important properties of this small viral protein.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066197PMC
http://dx.doi.org/10.3390/v13040617DOI Listing

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