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Impact of intrarenal arterial lesions on prognosis of IgA nephropathy: insights from a retrospective cohort study.
Ren Fail
December 2025
Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Background: IgA nephropathy (IgAN) presents a challenging spectrum of outcomes, often complicated by intrarenal arterial/arteriolar lesions (IALs) in affected individuals. Despite their clinical relevance, existing criteria for classifying and assessing the severity of these lesions remain undefined. This study aimed to establish semi-quantitative assessment criteria for grading IALs and to evaluate their prognostic significance in patients with IgAN.
View Article and Find Full Text PDFT-cell Engagers in Prostate Cancer.
Eur Urol
March 2025
Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. Electronic address:
Owing to the "cold" tumor immune microenvironment of prostate cancer, immune-targeting agents have shown limited efficacy in patients with advanced prostate cancer, highlighting the need for new therapies with novel mechanisms of action. In this context, T-cell engagers (TCEs), which induce T-cell-mediated killing of cancer cells by binding the CD3 receptor on T cells and a specific tumor antigen expressed on malignant cells, represent a promising therapeutic option. Multiple studies have explored the use of TCEs in previously treated patients with metastatic castration-resistant prostate cancer, and several ongoing trials are currently assessing novel TCEs either as single agents or in combinatorial regimens with molecules with a distinct mechanism of action (eg, androgen receptor pathway inhibitors and other immune-targeting agents).
View Article and Find Full Text PDFCapturing complete arch implant positions in two partial photogrammetry scans: Does it impact the accuracy of complete arch implant scans?
J Prosthet Dent
March 2025
Adjunct Professor, Department of Dental Medicine, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain.
Statement Of Problem: Extraoral photogrammetry (PG) systems can record implant positions in 1 scan or in 2 scans that are then merged. However, the accuracy of implant positions recorded in 2 partial photogrammetry scans is unknown.
Purpose: The purpose of this in vitro study was to compare the accuracy of complete arch implant scans recorded in 1 or 2 scans by using 3 extraoral PG systems.
The Transformative Role of Artificial Intelligence in Dentistry: A Comprehensive Overview. Part 1: Fundamentals of AI, and its Contemporary Applications in Dentistry.
Int Dent J
March 2025
Department of Restorative Dentistry, College of Dentistry, Ajman University, Ajman, United Arab Emirates; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Artificial intelligence (AI) holds immense promise in revolutionising dentistry, spanning, diagnostics, treatment planning and educational realms. This narrative review, in two parts, explores the fundamentals and the multifaceted potential of AI in dentistry. The current article explores the profound impact of AI in dentistry, encompassing diagnostic tools, treatment planning, and patient care.
View Article and Find Full Text PDFAnalysis of Femoral Flexion Angle Distribution and Range of Motion in Total Knee Arthroplasty.
J Arthroplasty
February 2025
Department of Orthopaedic Surgery, Northwell Orthopaedic Institute, Lenox Hill Hospital, New York, New York.
Background: Optimal coronal and rotational alignment in total knee arthroplasty is essential for satisfactory outcomes. There has been limited focus on sagittal alignment in assessing outcomes. This study investigated the impact of femoral implant flexion (FF) angle on knee kinematics and postoperative outcomes.
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