Slight power output manipulations around the maximal lactate steady state have a similar impact on fatigue in females and males.

Neuromuscular fatigue (NMF) and exercise performance are affected by exercise intensity and sex differences. However, whether slight changes in power output (PO) below and above the maximal lactate steady state (MLSS) impact NMF and subsequent performance (time to task failure, TTF) is unknown. This study compared NMF and TTF in females and males in response to exercise performed at MLSS, 10 W below (MLSS) and above (MLSS). Twenty participants (9 females) performed three 30-min constant-PO exercise bouts followed (1-min delay) by a TTF at 80% of the peak-PO. NMF was characterized by isometric maximal voluntary contractions (IMVC) and femoral nerve electrical stimulation of knee extensors [e.g., peak torque of potentiated high-frequency (Db100) and single twitch (TwPt)] before and immediately after the constant-PO and TTF bouts. IMVC declined less after MLSS (-18 ± 10%) compared to MLSS (-26 ± 14%) and MLSS (-31 ± 11%; all < 0.05), and the Db100 decline was greater after MLSS (-24 ± 14%) compared to the other intensities (MLSS: -15 ± 9%; MLSS: -18 ± 11%; all < 0.05). Females showed smaller reductions, relative to baseline, in IMVC and TwPt compared to males after constant-PO bouts (all < 0.05), this difference being not dependent on intensity. TTF was negatively impacted by increasing the PO in the constant-PO ( < 0.001), with no differences in end-exercise NMF ( > 0.05). Slight manipulations in PO around MLSS elicited great changes in the reduction of maximal voluntary force and impairments in contractile function. Although NMF was lower in females compared to males, the changes in PO around the MLSS impacted both sexes similarly. It is unknown whether minimum changes in power output (PO) below and above the maximal lactate steady state (MLSS) affect neuromuscular fatigue (NMF) development in females and males. The present data showed that a decrease or increase of 10 W in PO in relation to MLSS elicited lower and greater impairments in contractile function, respectively. Even though females had less of an overall decline in NMF than males, similar exercise intensity-dependent response occurred independently of sex.