Three pairs of enantiomeric sesquiterpenoids, (∓)-syringanoid A ( and ) and (±)-pinnatanoids A ( and ) and B ( and ), that represent an unprecedented 5/4/6 tricyclic backbone and a rare 6/7 bicyclic backbone, respectively, were isolated from the peeled stems of . The structures were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, a modified Mosher's method, and quantum chemical calculations. A plausible biotransformation pathway for - was proposed, and their cardiomyocyte-protective and anti-inflammatory activities were evaluated.
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