With the assistance of Ac in sulfoximine as a protecting group (PG) and MeOH as a de-PG agent, Pd-catalyzed multicomponent reactions were developed to access indene-fused medium-size sulfoximine heterocycles. The reactions proceeded smoothly under exceptionally mild conditions to produce polyheterocyclic sulfoximines with regiospecificity and good functional group tolerance. A double carbopalladation/syn-insertion of triple bond sequences was proposed tothis transformation.
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Pd-Catalyzed double carbopalladation/-insertion cascade reactions toward medium-size sulfoximine heterocycles.
Chem Commun (Camb)
April 2021
Key Laboratory of Functional Small Organic Molecules, Ministry of Education and Jiangxi Key Laboratory of Green Chemistry, College of Chemistry & Chemical Engineering, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi 330022, P. R. China.
With the assistance of Ac in sulfoximine as a protecting group (PG) and MeOH as a de-PG agent, Pd-catalyzed multicomponent reactions were developed to access indene-fused medium-size sulfoximine heterocycles. The reactions proceeded smoothly under exceptionally mild conditions to produce polyheterocyclic sulfoximines with regiospecificity and good functional group tolerance. A double carbopalladation/syn-insertion of triple bond sequences was proposed tothis transformation.
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