AI Article Synopsis
- Researchers synthesized diverse α-acylamino amide substructures using tritylamine in the Ugi reaction to develop new compounds.
- The use of Burgess-type reagents facilitated a cyclodehydration process that resulted in unique oxazole scaffolds featuring a sulfamide group at the 5-position.
- The synthetic method is efficient, uses easily accessible starting materials, and functions well under mild conditions while accommodating various functional groups, addressing a gap in oxazole compound development.
Article Abstract
Starting from a wide range of α-acylamino amide substructures synthesized using tritylamine as an ammonia surrogate in the Ugi reaction, Burgess-type reagents enable cyclodehydration and afford unprecedented oxazole scaffolds with four points of diversity, including a sulfamide moiety in the 5-position. The synthetic procedure employs readily available starting materials and proceeds smoothly under mild reaction conditions with good tolerance for a variety of functional groups, coming to fill a gap in the field of oxazole compounds.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289289 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.1c01002 | DOI Listing |
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