Chemogenetics: Beyond Lesions and Electrodes.

Neurosurgery

Department of Neurosurgery, Emory University, Atlanta, Georgia, USA.

Published: July 2021

The field of chemogenetics has rapidly expanded over the last decade, and engineered receptors are currently utilized in the lab to better understand molecular interactions in the nervous system. We propose that chemogenetic receptors can be used for far more than investigational purposes. The potential benefit of adding chemogenetic neuromodulation to the current neurosurgical toolkit is substantial. There are several conditions currently treated surgically, electrically, and pharmacologically in clinic, and this review highlights how chemogenetic neuromodulation could improve patient outcomes over current neurosurgical techniques. We aim to emphasize the need to take these techniques from bench to bedside.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279839PMC
http://dx.doi.org/10.1093/neuros/nyab147DOI Listing

Publication Analysis

Top Keywords

chemogenetic neuromodulation
8
current neurosurgical
8
chemogenetics lesions
4
lesions electrodes
4
electrodes field
4
field chemogenetics
4
chemogenetics rapidly
4
rapidly expanded
4
expanded decade
4
decade engineered
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!