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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992740 | PMC |
| http://dx.doi.org/10.5021/ad.2019.31.3.341 | DOI Listing |
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Transethosomal system for enhanced transdermal delivery and therapeutic effect of caryophyllene oxide.
Int J Pharm
December 2024
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Aim: This study focuses on the design and investigation a transethosomal formulation for enhanced topical delivery and improved analgesic activity of caryophyllene oxide. In addition, this work explores new potential mechanisms of analgesic activity of the active compound including alpha-amino-3-hydroxy-5-methyl-4-isooxazole-propionic acid (AMPA) and Cyclooxygenase 2 (COX-2).
Methods: The transethosomal system containing various caryophyllene concentrations was prepared.
The effect of novel mosquito bite prevention tools on Anopheles minimus landing and key secondary endpoints: semi-field evaluations in Thailand.
Malar J
December 2024
Armed Forces Research Institute of Medical Sciences, 315/6 Ratchawithi Road, Thung Phaya Thai, Ratchathewi, Bangkok, 10400, Thailand.
Background: The Greater Mekong Subregion (GMS) aims to eliminate all human malaria by 2030 and is making substantial progress toward this goal, with malaria increasingly confined to forest foci. These transmission foci are predominantly inhabited by ethnic minorities, local populations, and rural mobile and migrant populations working in mining and agriculture. The recommendations of the World Health Organization (WHO) on malaria elimination states that small population groups which constitute a large proportion of the malaria transmission reservoir should benefit from targeted strategies to reduce transmission overall.
View Article and Find Full Text PDFEvaluating the efficacy and safety of 2-methoxy-6-methylpyridine: a promising topical agent for gallstone dissolution in a porcine model.
Am J Transl Res
November 2024
Catholic Central Laboratory of Surgery, College of Medicine, The Catholic University of Korea Seoul 06591, Republic of Korea.
While methyl-tertiary butyl ether (MTBE) remains the sole clinical topical agent for gallstone dissolution, its utility is limited due to side effects, largely stemming from its relatively low boiling point (55°C). In this study, we introduced 2-methoxy-6-methylpyridine (MMP), a novel gallstone-dissolving compound featuring an aromatic moiety and a substantially higher boiling point (156°C), designed to mitigate these side effects. We conducted a comprehensive evaluation of the efficacy and potential toxicities of MMP compared to MTBE using both in vitro and in vivo models.
View Article and Find Full Text PDFSupramolecular Gels Derived from Primary Ammonium Salts of Naproxen and its Amino Acid Derivatives: Design, Synthesis, Structures and its Application as Anti-cancer Agent Against Melanoma Cell B16-F10.
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School of Chemical Sciences, Indian Association for the Cultivation of Science (IACS), 2 A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, West Bengal, 700032, India.
Article Synopsis
- Researchers developed a self-drug-delivery system using a supramolecular gelator called NAP-PHE∙PEA, derived from naproxen and amino acids, capable of gelling both water and organic solvents.* -
- The study explored the molecular interactions governing the gel's formation using techniques like 1H-NMR spectroscopy and X-ray diffraction to understand the gel-network structure and analyze various salt forms.* -
- NAP-PHE∙PEA demonstrated strong anti-cancer effects on certain cancer cell lines without harming normal cells, and its gel form exhibited beneficial properties such as self-healing and load-bearing, making it suitable for topical treatments.*
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