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Inhibition of Poly(I:C)-Induced Inflammation by Salvianolic Acid A in Skin Keratinocytes. | LitMetric

AI Article Synopsis

  • Skin keratinocytes play a key role in immune responses, but excessive inflammation can lead to chronic conditions like psoriasis.
  • The study tested salvianolic acid A (SAA) as a potential therapy for inflammatory skin diseases, finding that it significantly reduces inflammatory reactions in keratinocytes stimulated with poly(I:C).
  • Results showed that SAA inhibited the production of inflammatory cytokines and the activation of key signaling pathways, indicating its potential as a treatment for conditions like psoriasis.

Article Abstract

Background: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic skin disease such as psoriasis can be provoked.

Objective: We tried to screen the putative therapeutics for inflammatory skin disease, and found that salvianolic acid A (SAA) has an inhibitory effect on keratinocyte inflammatory reaction. The aim of this study is to demonstrate the effects of SAA in poly(I:C)-induced inflammatory reaction in skin keratinocytes.

Methods: We pre-treated keratinocytes with SAA then stimulated with poly(I:C). Inflammatory reaction of keratinocytes was verified using real-time polymerase chain reaction, enzyme-linked immunosorbent assay and Western blot.

Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, and CCL20. SAA inhibited poly(I:C)-induced activation of nuclear factor-κB signaling. And SAA also inhibited inflammasome activation, evidenced by decrease of IL-1β secretion. Finally, SAA markedly inhibited poly(I:C)-induced NLRP3 expression.

Conclusion: These results demonstrate that SAA has an inhibitory effect on poly(I:C)-induced inflammatory reaction of keratinocytes, suggesting that SAA can be developed for the treatment of inflammatory skin diseases such as psoriasis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992737PMC
http://dx.doi.org/10.5021/ad.2019.31.3.279DOI Listing

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