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A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson's Disease: Post-Hoc Analysis of Motor Outcomes.
J Clin Med
April 2023
College of Health and Medicine, Australian National University, Canberra, ACT 2601, Australia.
Emerging evidence is increasingly supporting the use of transcranial photobiomodulation (tPBM) to improve symptoms of neurodegenerative diseases, including Parkinson's disease (PD). The objective of this study was to analyse the safety and efficacy of tPBM for PD motor symptoms. The study was a triple blind, randomized placebo-controlled trial with 40 idiopathic PD patients receiving either active tPBM (635 nm plus 810 nm LEDs) or sham tPBM for 24 min per day (56.
View Article and Find Full Text PDFHelmet Tremor: A Rare Dystonic Tremor.
Ann Indian Acad Neurol
October 2020
Department of Neurology, Govt Medical College, Kottayam, Kerala, India.
Magnetic resonance-guided focused ultrasound for ablation of mesial temporal epilepsy circuits: modeling and theoretical feasibility of a novel noninvasive approach.
J Neurosurg
July 2020
Departments of1Neurological Surgery and.
Objective: The authors tested the feasibility of magnetic resonance-guided focused ultrasound (MRgFUS) ablation of mesial temporal lobe epilepsy (MTLE) seizure circuits. Up to one-third of patients with mesial temporal sclerosis (MTS) suffer from medically refractory epilepsy requiring surgery. Because current options such as open resection, laser ablation, and Gamma Knife radiosurgery pose potential risks, such as infection, hemorrhage, and ionizing radiation, and because they often produce visual or neuropsychological deficits, the authors developed a noninvasive MRgFUS ablation strategy for mesial temporal disconnection to mitigate these risks.
View Article and Find Full Text PDFA prospective single-blind study of Gamma Knife thalamotomy for tremor.
Neurology
November 2015
From the Department of Neurology and Movement Disorders (T.W., A.E., J.P.A.) and Department of Functional and Stereotactic Neurosurgery and Radiosurgery (R.C., J.R.), Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital; Institut de Neurosciences de la Timone (T.W., A.E., J.P.A.), UMR 7289, CNRS Aix-Marseille Université, Marseille, France; Université Grenoble Alpes (P.K.), GIN INSERM U318 and CHU de Grenoble, Movement Disorder Unit, Grenoble, France; CNRS-Aix-Marseille Université (M.V.), Laboratory of Cognitive Neurosciences, FR 3 C, Marseille, France; Unit of Functional Neurosurgery (M.H.), UCL Institute of Neurology, Queen Square, London, UK; Department of Clinical Neuroscience (M.H.), Umeå University, Sweden; and INSERM (R.C., J.R.), UMR 1106, Aix-Marseille Université, Marseille, France.
Objective: To evaluate the safety and efficacy of unilateral Gamma Knife thalamotomy (GKT) for treatment of severe tremor with a prospective blinded assessment.
Methods: Fifty patients (mean age: 74.5 years; 32 men) with severe refractory tremor (36 essential, 14 parkinsonian) were treated with unilateral GKT.
Report of whole-brain radiation therapy in a patient with an implanted deep brain stimulator: important neurosurgical considerations and radiotherapy practice principles.
J Neurosurg
April 2016
Department of Radiation Oncology, Taussig Cancer Institute.
Patients with implanted neuromodulation devices present potential challenges for radiation therapy treatment planning and delivery. Although guidelines exist regarding the irradiation of cardiac pacemakers and defibrillators, fewer data and less clinical experience exist regarding the effects of radiation therapy on less frequently used devices, such as deep brain stimulators. A 79-year-old woman with a history of coarse tremors effectively managed with deep brain stimulation presented with multiple intracranial metastases from a newly diagnosed lung cancer and was referred for whole-brain radiation therapy.
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