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Background: A risk haplotype in characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment responses is not well understood.

Objectives: We aimed to determine the impact of the risk haplotype on the metabolomic profile during a lifestyle intervention (LSI).

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Exploring the potential anti-thyroid activity of Acetyl-L-carnitine: Lactoperoxidase inhibition profile, iodine complexation and scavenging power against HO. Experimental and theoretical studies.

Spectrochim Acta A Mol Biomol Spectrosc

May 2024

Centro de Química Inorgánica (CEQUINOR-CONICET-UNLP- Asoc CICPBA)-Departamento de Química-Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Boulevard 120 entre 60 y 64, C.C.962- (B1900AVV) -1900 La Plata, Argentina. Electronic address:

L-Acetylcarnitine (ALC), a versatile compound, has demonstrated beneficial effects in depression, Alzheimer's disease, cognitive impairment, and other conditions. This study focuses on its antithyroid activity. The precursor molecule, L-carnitine, inhibited the uptake of triiodothyronine (T3) and thyroxine (T4), and it is possible that ALC may reduce the iodination process of T3 and T4.

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Ethnopharmacological Relevance: Saussurea costus (Falc.) Lipschitz. is one of the most reputed medicinal plants as a traditional medicine in the Arab and Middle East regions in the treatment of thyroid disorders, however, more investigations are needed to fully understand its effectiveness and mechanism of action.

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Article Synopsis
  • Dysthymia, or persistent depressive disorder, is linked to longer treatment durations, increased healthcare usage, and significant comorbidity, warranting a systematic review of treatment options over the past decade.
  • The systematic review, conducted following PRISMA guidelines, examined various databases to compare the efficacy of pharmacological treatments for dysthymia against placebo and standard care.
  • Findings indicate that SSRIs and SNRIs are effective treatments for dysthymia, while further research on L-Acetylcarnitine in elderly patients is needed; however, there is a notable lack of studies on ongoing maintenance therapy for this condition.
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Background: Undesired intrathecal injections represent an important subset of medical errors, albeit rare. Clinical effects depend on the type and concentration of drug(s) injected. Here we report on the case of a healthy woman with persistent low back pain, treated with a paravertebral injection of lidocaine, thiocolchicoside, and L-acetylcarnitine at an orthopedic practice.

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