AI Article Synopsis
- Curcumin, a compound found in turmeric, when combined with dutasteride, a medication that inhibits testosterone conversion, was studied for its effects on LNCaP prostate cancer cells.
- The combination treatment significantly reduced cell proliferation, increased apoptosis rates, and lowered levels of testosterone and dihydrotestosterone in these cancer cells.
- Moreover, the combination inhibited the secretion of prostate-specific antigen in a dose-dependent manner, suggesting it may disrupt hormonal activity within tumors.
Article Abstract
Background/aim: Curcumin is a natural compound of turmeric, which inhibits prostate cancer cell proliferation. This study examined whether treatment of LNCaP prostate cancer cells with the combination of curcumin and dutasteride, a 5-alpha reductase inhibitor, affect proliferation and the amount of testosterone and dihydrotestosterone.
Materials And Methods: LNCaP Cells were incubated with curcumin or the combination of curcumin and dutasteride and cell proliferation was measured at 72 h. LC-MS/MS was used to determine testosterone and dihydrotestosterone concentrations in prostate cancer cells.
Results: Curcumin combined with dutasteride suppressed proliferation and affected apoptosis of LNCaP cells. The combination of curcumin and dutasteride also reduced the amount of testosterone and dihydrotestosterone in LNCaP cells. The secretion of prostate-specific antigen was inhibited by the combination treatment in a dose-dependent manner.
Conclusion: Treatment with the combination of curcumin and dutasteride may interfere with the intra-tumoral androgen activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193285 | PMC |
| http://dx.doi.org/10.21873/invivo.12396 | DOI Listing |
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