Effect of ambient fine particulates (PM) on hospital admissions for respiratory and cardiovascular diseases in Wuhan, China.

Background: Positive associations between ambient PM and cardiorespiratory disease have been well demonstrated during the past decade. However, few studies have examined the adverse effects of PM based on an entire population of a megalopolis. In addition, most studies in China have used averaged data, which results in variations between monitoring and personal exposure values, creating an inherent and unavoidable type of measurement error.

Methods: This study was conducted in Wuhan, a megacity in central China with about 10.9 million people. Daily hospital admission records, from October 2016 to December 2018, were obtained from the Wuhan Information center of Health and Family Planning, which administrates all hospitals in Wuhan. Daily air pollution concentrations and weather variables in Wuhan during the study period were collected. We developed a land use regression model (LUR) to assess individual PM exposure. Time-stratified case-crossover design and conditional logistic regression models were adopted to estimate cardiorespiratory hospitalization risks associated with short-term exposure to PM. We also conducted stratification analyses by age, sex, and season.

Results: A total of 2,806,115 hospital admissions records were collected during the study period, from which we identified 332,090 cardiovascular disease admissions and 159,365 respiratory disease admissions. Short-term exposure to PM was associated with an increased risk of a cardiorespiratory hospital admission. A 10 μg/m increase in PM (lag0-2 days) was associated with an increase in hospital admissions of 1.23% (95% CI 1.01-1.45%) and 1.95% (95% CI 1.63-2.27%) for cardiovascular and respiratory diseases, respectively. The elderly were at higher PM-induced risk. The associations appeared to be more evident in the cold season than in the warm season.

Conclusions: This study contributes evidence of short-term effects of PM on cardiorespiratory hospital admissions, which may be helpful for air pollution control and disease prevention in Wuhan.