AI Article Synopsis
- The study investigated whether Biozzi mice with experimental autoimmune encephalomyelitis (EAE) mimic the disease progression and immune responses seen in progressive multiple sclerosis (MS).
- Findings showed that chronic EAE in these mice displayed characteristics such as relapsing disease stages, altered blood-brain barrier (BBB) function, and the formation of ectopic lymphoid tissues that relate to tissue damage.
- The immune response shifted from being T cell-dominant during relapses to B cell-dominant in later stages, suggesting that late chronic EAE may serve as an effective model for researching treatments for progressive MS.
Article Abstract
We explored whether experimental autoimmune encephalomyelitis (EAE) in Biozzi mice recapitulates temporal dynamics of tissue injury, immune-pathogenesis and CNS compartmentalization occurring in progressive multiple sclerosis (MS). Chronic EAE exhibited relapsing and progressing disease, partial closure of BBB, reduced tissue inflammatory activity, and development of meningeal ectopic lymphoid tissue, directly opposing (potentially driving) spinal subpial demyelinated plaques. A T cell predominant disease during relapses transformed into a B cell predominant disease in late chronic EAE, with high serum anti-MOG reactivity. Thus, late chronic Biozzi EAE recapitulates essential features of progressive MS, and is suitable for developing disease modifying and regenerative therapies.
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| http://dx.doi.org/10.1016/j.jneuroim.2021.577582 | DOI Listing |
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