Purpose: To evaluate the influence of low-dose protocols, with different numbers of basis images, on the precision of linear bone measurements in CBCT images.
Materials And Methods: Five polyurethane mandibles, with different levels of bone resorption, were used in this in vitro study. To obtain the reference standard, landmarks were made in the mandibular superior and buccal cortices, and then a digital caliper was used to measure the bone height and thickness at these regions. CBCT images were obtained with the PaX-i3D (Vatech) unit set at 50 kV, 4 mA, 0.2-mm voxel size and 50 × 50-mm field of view. Keeping these parameters fixed, each mandible was scanned twice, with different protocols: Low dose (L) had an acquisition time of 24 seconds and 720 basis images, and ultralow dose (UL) had an acquisition time of 15 seconds and 450 basis images. Then, measurements of bone height and thickness were performed on the images, using the previously determined landmarks as reference. The obtained data were submitted to statistical analysis, with a significance level of .05. Analysis of variance, Student t test, and intraclass correlation coefficient were employed.
Results: Regarding bone height, there were no significant differences between the measurements obtained with the L and UL protocols (P = .8648). Additionally, the L and UL protocols did not differ in relation to the reference standard (P = .8717 and P = .9928, respectively). Likewise, there were no significant differences between the measurements obtained with the L and UL protocols (P = .7969) for bone thickness, nor between these protocols and the gold standard (P = .7455).
Conclusion: Considering the great demand for precise measurements in implantology, protocols of low-dose radiation can be used without compromising clinical planning.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.11607/jomi.8773 | DOI Listing |
PLoS Comput Biol
January 2025
IRSD-Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
Understanding the interplay between biology and mechanics in tissue architecture is challenging, particularly in terms of 3D tissue organization. Addressing this challenge requires a biological model enabling observations at multiple levels from cell to tissue, as well as theoretical and computational approaches enabling the generation of a synthetic model that is relevant to the biological model and allowing for investigation of the mechanical stresses experienced by the tissue. Using a monolayer human colon epithelium organoid as a biological model, freely available tools (Fiji, Cellpose, Napari, Morphonet, or Tyssue library), and the commercially available Abaqus FEM solver, we combined vertex and FEM approaches to generate a comprehensive viscoelastic finite element model of the human colon organoid and demonstrated its flexibility.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, China.
Rationale: Developmental and epileptic encephalopathy (DEE) defines a group of severe and heterogeneous neurodevelopmental disorders. The voltage-gated potassium channel subfamily 2 voltage-gated potassium channel α subunit encoded by the KCNB1 gene is essential for neuronal excitability. Previous studies have shown that KCNB1 variants can cause DEE.
View Article and Find Full Text PDFCells
January 2025
Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand.
The overall goal of this work was to assess the ability of Natural Killer cells to kill cultures of patient-derived glioblastoma cells. Herein we report impressive levels of NK-92 mediated killing of various patient-derived glioblastoma cultures observed at ET (effector: target) ratios of 5:1 and 1:1. This enabled direct comparison of the degree of glioblastoma cell loss across a broader range of glioblastoma cultures.
View Article and Find Full Text PDFEur Heart J
January 2025
Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Manuel de Falla, 1, 28222 Majadahonda, Madrid, Spain.
Development of specific therapies addressing the underlying diseases' mechanisms constitutes the basis of precision medicine. Transthyretin cardiac amyloidosis (ATTR-CM) is an exemplar of precise therapeutic approach in the field of heart failure and cardiomyopathies. A better understanding of the underlying pathophysiology, more precise data of its epidemiology, and advances in imaging techniques that allow non-invasive diagnosis have fostered the development of new and very effective specific therapies for ATTR-CM.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
December 2024
Division of Cardiac Surgery, Inova Heart and Vascular Institute, Inova Health Systems, Falls Church, Virginia.
Background: DeBakey type I aortic dissections (AD) are most frequently treated with hemiarch repair. A subset of patients demonstrates persistent distal end-organ ischemia secondary to persistent true lumen (TL) compression. We describe the use of bare metal stent grafting across the residual arch dissection with the Zenith Dissection Endovascular Stent (ZDES, Cook Medical) in 7 patients with type I AD that was repaired in a hemiarch configuration with a compromised distal TL and organ malperfusion.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!