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The molar dose of FAPI administered impacts on the FAP-targeted PET imaging and therapy in mouse syngeneic tumor models.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
Purpose: Since fibroblast activation protein (FAP), one predominant biomarker of cancer associated fibroblasts (CAFs), is highly expressed in the tumor stroma of various epidermal-derived cancers, targeting FAP for tumor diagnosis and treatment has shown substantial potentials in both preclinical and clinical studies. However, in preclinical settings, tumor-bearing mice exhibit relatively low absolute FAP expression levels, leading to challenges in acquiring high-quality PET images using radiolabeled FAP ligands (FAPIs) with low molar activity, because of which a saturation effect in imaging is prone to happen. Moreover, how exactly the molar dose of FAPI administered to a mouse influences the targeted PET imaging and radiotherapy remains unclear now.
View Article and Find Full Text PDFA Cytosolic Phosphoglucose Isomerase, OsPGI1c, Enhances Plant Growth and Herbivore Resistance in Rice.
Int J Mol Sci
December 2024
State Key Laboratory of Rice Biology & Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.
Glucose-6-phosphate isomerase (PGI), a key enzyme that catalyzes the reversible conversion of glucose-6-phosphate and fructose-6-phosphate, plays an important role in plant growth, development, and responses to abiotic stresses and pathogen infections. However, whether and how PGI modulates herbivore-induced plant defenses remain largely unknown. The Brown planthopper (BPH, ) is a devastating insect pest of rice, causing significant damage to rice plants through feeding, oviposition, and disease transmission, resulting in great yield losses.
View Article and Find Full Text PDFPrediction of Potential Habitat Distributions and Climate Change Impacts on the Rare Species (Magnoliaceae) in China Based on MaxEnt.
Plants (Basel)
December 2024
College of Forestry, Guizhou University, Guiyang 550025, China.
Changes in species' habitats provide important insights into the effects of climate change. , a critically endangered species endemic to karst ecosystems, has a highly restricted distribution and is a key biological resource. Despite its ecological importance, the factors influencing its habitat suitability and distribution remain poorly understood.
View Article and Find Full Text PDFThe Spatial Relationship Between Two Sympatric Pheasant Species and Various Human Disturbance Activities.
Animals (Basel)
January 2025
School of Life Sciences, Anhui University, Hefei 230601, China.
Establishing and managing nature reserves to mitigate wildlife habitat loss and fragmentation is challenging, particularly in the face of increasing human activity. To understand how wildlife coexists in environments affected by anthropogenic disturbances, we conducted a 19-month survey examining the Reeves's pheasant () and Koklass pheasant () in the Anhui Tianma National Nature Reserve, China. Previous studies of large terrestrial birds focused primarily on livestock impacts, with less attention given to other human activities.
View Article and Find Full Text PDFComparative Metagenomic Analysis of the Gut Microbiota of Captive Pangolins: A Case Study of Two Species.
Animals (Basel)
December 2024
College of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Pangolins, one of the most trafficked mammals, face significant health challenges in captivity, including digestive disorders and immune dysfunctions. These issues are closely linked to alterations in their gut microbiota, which play vital roles in the host metabolism, immunity, and overall health. This study investigated the differences in the gut microbiota composition and function between two pangolin species, Chinese pangolins () and Malayan pangolins (), under identical captive conditions to better understand their ecological adaptability and health implications.
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