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| http://dx.doi.org/10.4103/1673-5374.313032 | DOI Listing |
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Of criminals and cancer: The importance of social bonds and innate morality on cellular societies.
Cells Dev
December 2024
School of Biological Sciences, University of Utah, Salt Lake City, UT, United States; Department of Mathematics, University of Utah, Salt Lake City, UT, United States; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.
The current dogma in cancer biology contends that cancer is an identity problem: mutations in a cell's DNA cause it to "go rogue" and proliferate out of control. However, this largely ignores the role of cell-cell interaction and fails to explain phenomena such as cancer reversion, the existence of cancers without mutations, and foreign-body carcinogenesis. In this proof-of-concept paper, we draw on criminology to propose that cancer may alternatively be conceptualized as a relational problem: Although a cell's genetics is essential, the influence of its interaction with other cells is equally important in determining its phenotype.
View Article and Find Full Text PDFPhylogenomic analyses of Blattodea combining traditional methods, incremental tree-building, and quality-aware support.
Mol Phylogenet Evol
November 2024
Institut de Systématique, Evolution, Biodiversité (ISYEB), UMR7205, Muséum national d'Histoire naturelle (MNHN), CNRS, Sorbonne Université, EPHE, Université des Antilles, CP50 Paris, France.
Article Synopsis
- Despite advancements in genomics, assessing uncertainty in phylogenomic studies remains challenging, particularly in the phylogenetics of cockroaches and termites, where inconsistencies persist across different research.
- A new phylogenetic analysis of Blattodea was conducted using three methods, including a novel "tiered phylogenetic inference," which integrates data quality into the analysis to better gauge the reliability of phylogenetic relationships.
- This approach highlighted problematic areas with previously high support but low data quality, leading to clearer resolutions of several phylogenetic uncertainties, particularly regarding the relationships within Blaberidae and other families.
Effective dispersal patterns in prairie plant species across human-modified landscapes.
Mol Ecol
June 2024
Department of Biology, Portland State University, Portland, Oregon, USA.
Effective dispersal among plant populations is dependent on vector behaviour, landscape features and availability of adequate habitats. To capture landscape feature effects on dispersal, studies must be conducted at scales reflecting single-generation dispersal events (mesoscale). Many studies are conducted at large scales where genetic differentiation is due to dispersal occurring over multiple generations, making it difficult to interpret the effects of specific landscape features on vector behaviour.
View Article and Find Full Text PDFA guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma.
Cancer Gene Ther
June 2024
Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Osteosarcoma is the most prevalent malignant bone tumour in children, adolescents and young adults. Despite a multitude of aberrations present in osteosarcoma genomes, no recurrent driver mutations have been identified to date. In addition, unlike for other sarcoma entities, no functional fusion proteins resulting from chromosomal rearrangements have been reported.
View Article and Find Full Text PDFA new Rogue-like phage UDF157lw to control O157:H7.
Front Microbiol
January 2024
Produce Safety and Microbiology Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA, United States.
Introduction: Shiga toxin-producing (STEC) O157:H7 is one of the notorious foodborne pathogens causing high mortality through the consumption of contaminated food items. The food safety risk from STEC pathogens could escalate when a group of bacterial cells aggregates to form a biofilm. Bacterial biofilm can diminish the effects of various antimicrobial interventions and enhance the pathogenicity of the pathogens.
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