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Effectively simplified Adriamycin-induced chronic kidney disease mouse model: Retro-orbital vein injection versus tail-vein injection.
Animal Model Exp Med
January 2025
Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Towada, Japan.
This study aimed to investigate the impact of administration routes in establishing the Adriamycin (ADR)-induced chronic kidney disease (CKD) model. Using BALB/c mice, we compared the effects of conventional tail-vein injection (TV10, 10 mg/kg) to those of retro-orbital sinus (orbital vein) injection (OV10, 10 mg/kg; OV8, 8 mg/kg). The results indicated that the OV10 group exhibited CKD pathology similar to the TV10 group, with both groups demonstrating significantly higher urinary albumin/creatinine ratio (p < 0.
View Article and Find Full Text PDFImproving ADR reporting in Jordan: a qualitative exploration of pharmacists' perspectives.
Front Med (Lausanne)
January 2025
Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Background: Community pharmacists are most accessible to patients. Hence, they have a crucial role in ensuring drug safety by detecting and reporting adverse drug reactions (ADRs). However, there may be gaps in their knowledge of ADR reporting systems and barriers they face in reporting.
View Article and Find Full Text PDFIdentifying strategies to improve adverse drug reporting through key informant interviews among community pharmacists in a developing country.
Sci Rep
July 2024
Procurement and Supply Chain Unit, United Nations Development Programme (Global Fund Project), Harare, Zimbabwe.
Reporting adverse drug reactions (ADRs) is fundamental in improving medication safety. Community pharmacists (CPs) being the first point of contact for individuals seeking healthcare in a community, play a significant role in ADR reporting. However, this has been poorly implemented in many countries including Nigeria.
View Article and Find Full Text PDFPrediction of adverse drug reactions in geriatric patients admitted to intensive care units.
Farm Hosp
November 2024
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil.
Introduction: Intensive Care Units (ICUs) pose challenges in managing critically-ill patients with polypharmacy, potentially leading to Adverse Drug Reactions (ADRs), particularly in the elderly.
Objective: To evaluate whether the severity and clinical prognosis scores used in ICUs correlate with the prediction of ADRs in aged patients admitted to an ICU.
Methods: A cohort study was conducted in a Brazilian University Hospital ICU.
Prediction of adverse drug reactions in geriatric patients admitted to intensive care units.
Farm Hosp
November 2024
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Introduction: Intensive care units (ICUs) pose challenges in managing critically ill patients with polypharmacy, potentially leading to adverse drug reactions (ADRs), particularly in the elderly.
Objective: To evaluate whether the severity and clinical prognosis scores used in ICUs correlate with the prediction of ADRs in aged patients admitted to an ICU.
Methods: A cohort study was conducted in a Brazilian University Hospital ICU.
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