Chromosomal instability: Stretching the role of checkpoint silencing.

Curr Biol

Chromosome Instability and Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal. Electronic address:

Published: April 2021

Microtubule attachments to kinetochores cause their deformation - a murky phenomenon known as intra-kinetochore stretching. A new study proposes that intra-kinetochore stretching is independent of microtubule-pulling forces and mediates efficient spindle assembly checkpoint silencing to prevent chromosomal instability.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610743PMC
http://dx.doi.org/10.1016/j.cub.2021.02.014DOI Listing

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