AI Article Synopsis
- Six cases of a rare brain condition called tumor-like mass lesion (ML-PACNS) were studied, with an average patient age of 44.5 years, mostly men.
- Common symptoms included headaches, neurological deficits, and seizures, with MRI showing both unifocal and multifocal lesions characterized by unique internal features.
- Pathological analysis revealed varied forms of vasculitis, and the findings suggest that younger patients may primarily present with seizures; MRI characteristics could help in diagnosing this condition.
Article Abstract
Tumor-like mass lesion is a rare subtype of primary angiitis of the central nervous system (ML-PACNS). This report describes six patients of histologically verified ML-PACNS. The mean age was 44.5 years (range 25-68) and four were males. Presenting symptoms headache (5), focal neurologic deficits (5), and seizures (4). On magnetic resonance imaging (MRI) the lesion was unifocal in two and multifocal in four patients. Consistent radiological findings were mass lesions with heterointense internal morphology with areas of diffusion restriction (DWI), and variable post-contrast enhancement. Pathologically vasculitis was classified as: Granulomatous in one, necrotizing in two and lymphocytic in three. There were two deaths. In conclusion patients with ML-PACNS are likely to be younger and more likely to present with seizures. MRI lesions with hetrointense internal morphology with areas of DWI was a consistent finding and may be a clue for the diagnosis of ML-PACNS.
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| http://dx.doi.org/10.4103/0028-3886.314536 | DOI Listing |
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