Measuring Perfusion: Intravoxel Incoherent Motion MR Imaging.

The signal acquired in vivo using a diffusion-weighted MR imaging (DWI) sequence is influenced by blood motion in the tissue. This means that perfusion information from a DWI sequence can be obtained in addition to thermal diffusion, if the appropriate sequence parameters and postprocessing methods are applied. This is commonly regrouped under the denomination intravoxel incoherent motion (IVIM) perfusion MR imaging. Of relevance, the perfusion information acquired with IVIM is essentially local, quantitative and acquired without intravenous injection of contrast media. The aim of this work is to review the IVIM method and its clinical applications.