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Clinical Manifestations.
Alzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Mild Cognitive Impairment (MCI) is a cognitive decline that is greater than expected for an individual's age and level of education, but which does not interfere with functionality. It may be divided into amnestic (when it predominantly affects memory) and non-amnestic (other cognitive domains). One of the cognitive functions that may be affected by MCI is language.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Background: Traditional pen-and-paper neuropsychological assessments fail to capture subtle cognitive changes in the early stages of Alzheimer's disease (AD). Remote and unsupervised digital assessments available on smartphones, tablets, and personal computers may offer a solution to this by increasing the amount and types of data available to researchers and clinicians, while simultaneously improving ecological validity and alleviating patient burden. As these remote and unsupervised digital cognitive assessment tools become more widely available, it is important that they are validated in a systematic way.
View Article and Find Full Text PDFMonitoring and preventing foodborne outbreaks: are we missing wastewater as a key data source?
Ital J Food Saf
November 2024
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia.
In 2022, the number of foodborne outbreaks in Europe increased by 43.9%, highlighting the need to improve surveillance systems and design outbreak predictive tools. This review aims to assess the scientific literature describing wastewater surveillance to monitor foodborne pathogens in association with clinical data.
View Article and Find Full Text PDFThe role of the circadian timing system in sarcopenia in old age: a scoping review.
Eur Geriatr Med
January 2025
Department of Biomedical and Neuromotor Science, Alma Mater Studiorum Università di Bologna, Ravenna Campus, Ravenna, Italy.
Purpose: Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.
View Article and Find Full Text PDFCentral statistical monitoring in clinical trial management: A scoping review.
Clin Trials
January 2025
Central Monitoring and Data Analytics, GSK, Brentford, UK.
Background: Clinical trials handle a huge amount of data which can be used during the trial to improve the ongoing study conduct. It is suggested by regulators to implement the remote approach to evaluate clinical trials by analysing collected data. Central statistical monitoring helps to achieve that by employing quantitative methods, the results of which are a basis for decision-making on quality issues.
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