Cyclodextrin based nanosponges are the designed nanocarriers for the projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three-dimensional, mesh-like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small-sized or large-sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability and stability enhancement purposes. This system is also pliable for co-delivery of pharmaceutical entities, improving therapeutic efficacy and patient compliance. If the surface of nanosponge is coupled with an appropriate ligand, even a target specific drug delivery can be achieved. It has a variety of applications in the field of pharmacy for the delivery of tricky drug molecules, proteins, enzymes, natural moieties and gaseous compounds. The list of its applications further widens with the development of nanodiagnostics, nanosensors, biomimetics and scaffolds based on nanosponges. The sudden explosion of research in this working area signifies cyclodextrin nanosponge based products in the market soon.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1567201818666210423091250 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Calixarene-Based Magnetic Nanosponge Decorating AgNPs for Rapid and Selective Surface-Enhanced Raman Scattering Analysis in Complex Samples.
Anal Chem
January 2025
School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Rapid and accurate analysis of trace targets in complex samples remains an enormous challenge. Herein, the calix[]arene-based magnetic cross-linked polymer decorating AgNPs, abbreviated FeO-CXA-DAB@AgNPs nanosponge, was developed for fast surface-enhanced Raman scattering (SERS) analysis in complex samples. The FeO-CXA-DAB@AgNPs nanosponge surface was constructed by high-density CXA units with special cavity size and structure, which could selectively recognize and enrich targets to the sensing surface by the host-guest effect and molecule interactions.
View Article and Find Full Text PDFCyclodextrin-Nanosponge-Loaded Cyclo-Oxygenase-2 Inhibitor-Based Topical Gel for Treatment of Psoriatic Arthritis: Formulation Design, Development, and Evaluations.
Pharmaceuticals (Basel)
November 2024
Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.
Psoriatic arthritis (PsA), a chronic inflammatory disease, mainly affects the joints, with approximately 30% of psoriasis patients eventually developing PsA. Characterized by both innate and adaptive immune responses, PsA poses significant challenges for effective treatment. Recent advances in drug delivery systems have sparked interest in developing novel formulations to improve therapeutic outcomes.
View Article and Find Full Text PDFModulating exosomal communication between macrophages and melanoma cancer cells via cyclodextrin-based nanosponges loaded with doxorubicin.
Nanotoxicology
December 2024
Deartment of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
The cellular components of the tumor microenvironment (TME) comprise cancer cells and nonmalignant cells including stromal and immune cells. Exosomes are extracellular vesicles secreted by various types of cells that play a crucial role in intercellular communications within TME. The main goal of this study was to elucidate how exosomes of macrophage cells treated with doxorubicin (DOX) and DOX-loaded cyclodextrin-based nanosponges (DOX-CDNSs), affect melanoma cancer cell proliferation.
View Article and Find Full Text PDFSulphated zirconia on cyclodextrin nanosponge: A carbohydrate-based catalyst for conversion of mono-saccharides to 5-hydroxymethylfurfural.
Carbohydr Polym
February 2025
Gas Conversion Department, Faculty of Petrochemicals, Iran Polymer and Petrochemical Institute, PO Box 14975-112, Tehran, Iran. Electronic address:
To expand the utility of cyclodextrin nanosponges for catalytic purpose, β-cyclodextrin nanosponge was prepared via melting method and then utilized as a catalyst support for the stabilization of sulphated zirconia The resulting catalyst, denoted as CDNS-SO/ZrO, was then applied as a heterogeneous acidic catalyst for conversion of fructose to 5-hydroxymethylfurfural. The results, underpinned that the catalytic activity of CDNS-SO/ZrO, was superior to that of ZrO and SO/ZrO, confirming the role of sulfonation of ZrO and immobilization of SO/ZrO on CDNS in catalysis. To optimize the reaction parameters and achieve maximum yield of the desired product, Response Surface Method that is an accurate procedure for appraising the impacts of the reaction variables was employed and it was found that using 35 wt% CDNS-SO/ZrO at 80 °C, HMF in 93 % yield was achieved in 45 min.
View Article and Find Full Text PDFSynthesis, (bio)degradation, and utilization of starch-derived biopolymers in defined hard waters.
Carbohydr Polym
February 2025
Department of Chemistry, Nanomaterials for Industry and Sustainability Centre (NIS Centre), Università degli Studi di Torino, Via P. Giuria 7, 10125 Turin, Italy.
Climate change is causing a change in local rainfall, which generally brings with it a reduction in rainfall and, consequently, an increase in water hardness. This study explores the suitability and stability of various dextrin-derived polymers for cation removal in simulated hard water conditions. Thermal analysis and Fourier-transform infrared spectroscopy confirm the polymers' thermal stability and proper formation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!