Adapted sailing is a Paralympic sport in which sailors with different types of disabilities can compete in the same event. According to 2.4mR Class, eligible impairments include limb deficiency and vision impairment. However, it is still unknown the variables that determine performance. Thus, the objectives of this study were: (i) to identify the variables that determine the sailing performance, (ii) to analyse the influence of the type of impairment on sailing performance, and (iii) analyse the influence of the wind force on sailing performance. Thirty-three elite sailors with disabilities participated and were divided into three groups according to the type of impairment: affectation of upper, lower, or upper and lower limbs. Participants were evaluated during three 2.4mR class World Cups and the following variables were assessed: velocity made good, distance and manoeuvres in upwind-downwind courses and type of impairment. Those sailors with better performance travelled a shorter distance during downwind sailing. The results showed that performance was not affected by which category the sailor was placed according to the type of impairment. The sailors with a lesser disability perform better when the wind is medium and high.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/02640414.2021.1917871 | DOI Listing |
Small
January 2025
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Emerging evidence demonstrates that inducing ferroptosis, a nonapoptotic programmed cell death mode, holds significant potential for tumor treatment. However, current ferroptosis strategies utilizing exogenous Fenton-type heavy metal species or introducing glutathione (GSH)/glutathione peroxidase 4 (GPX4) suppressants are hampered by latent adverse effects toward organisms, while utilizing endogenous iron may cause undesirable tumor angiogenesis through specific signaling pathways. Here, a ferric ion (Fe)-responsive and DNAzyme-delivered coordination nanosystem (ZDD) is developed to achieve a novel scheme of synergistic tumor-specific ferroptosis and gene therapy, which modulates and harnesses the endogenous iron in tumors for inducing ferroptosis while intercepting tumor angiogenesis to enhance therapeutic efficacy.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Center of Digital Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Background: Establishing accurate, reliable, and convenient methods for enamel segmentation and analysis is crucial for effectively planning endodontic, orthodontic, and restorative treatments, as well as exploring the evolutionary patterns of mammals. However, no mature, non-destructive method currently exists in clinical dentistry to quickly, accurately, and comprehensively assess the integrity and thickness of enamel chair-side. This study aims to develop a deep learning work, 2.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
The First Clinical College of Medicine, Fujian Medical University, Fuzhou, 350005, China.
Ulcerative colitis (UC) remains an intractable and relapsing disease featured by intestinal inflammation. The anti-UC activity of Akkermansia muciniphila (AKK), an intestinal microorganism, has been widely investigated. The current work is to explore the impacts of AKK on UC and its possible reaction mechanism.
View Article and Find Full Text PDFImmun Inflamm Dis
January 2025
Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Objective: To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features.
Methods: Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC).
Results: Significant differences in CXCR5 cg19599951 methylation were found between RA and HC, as well as AS and SLE.
Angew Chem Int Ed Engl
January 2025
Department of Materials Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, P. R. China.
All-solid-state lithium metal batteries (LMBs) are regarded as next-generation devices for energy storage due to their safety and high energy density. The issues of Li dendrites and poor mechanical compatibility with electrodes present the need for developing solid-state electrolytes with high stiffness and damping, but it is a contradictory relationship. Here, inspired by the superstructure of tooth enamel, we develop a composite solid-state electrolyte composed of amorphous ceramic nanotube arrays intertwined with solid polymer electrolytes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!