AI Article Synopsis
- Researchers isolated a new sesquiterpene (chlorantholide G), a sesquiterpene dimer (elatiolactone), and two new diterpenes (elatiorlabdane B and C) from the aerial parts of a plant, along with 51 known compounds.
- The new structures and their configurations were determined using techniques like mass spectrometry, NMR, and electronic circular dichroism.
- Among all the isolated compounds, two showed significant anti-hDHODH activity, with IC values of 18.7 µM and 30.7 µM.
Article Abstract
A new sesquiterpene, chlorantholide G (1: ), a new sesquiterpene dimer, elatiolactone (2: ), and 2 new diterpenes, elatiorlabdane B (3: ) and elatiorlabdane C (4: ), together with 51 known compounds, were isolated from the aerial parts of . The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4,6)-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone (5: ) and (4,5,9,10)-8(17),12,14-labdatrien-18-oic acid (29: ) were the most active compounds with IC values of 18.7 and 30.7 µM, respectively.
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| http://dx.doi.org/10.1055/a-1449-2642 | DOI Listing |
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